Regulatin' genes

On February 25, 2009, the YouTube shown below was uploaded - introducing the next, "Genome Based Generation" that will make "Genome Based Economy" happen. After 3 or so weeks, the cameo was viewed 37,000 times, which shows a universal appeal and acceptance.

Most significantly, the two obsolete axioms of Genomics (as we used to know it), "The Central Dogma of Molecular Biology" (Crick, 1956) and the "Junk DNA" scientific misunderstanding (Ohno, 1972) are swept aside. An era is gone (minus a handful of morons).

View Regulatin' Genes YouTube

The 21st Century "Genome Based Generation" throws old papers away at their 7th second of the cameo, when the first script appears. Proteins recursing to the DNA to regulate genome function used to be, for half a Century something that "never happens" (Crick, 1956; "The Central Dogma of Molecular Biology"). A paper on June 14, 2008 and a Google Tech YouTube on October 30, 2008 blew not one, but two "obsolete axioms" away. The above script takes it for granted that from a DNA > RNA > Proteins there is a recursion to DNA "regulatin' genes". Bye-bye, "Central Dogma"...

View Regulatin' Genes YouTube

After only 1:20 (less than one and a half minutes...) the "Junk DNA" myth is destroyed by the pop-cult: "On that non-coding region" (formerly, "Junk") "you might get to regulate a gene". Bye-bye "Junk DNA".

LYRICS of "Regulatin' genes" - observe that the "Plain English" message of McFadden is "encoded" into the lyrics much like the genome is full of self-similar fragments, repetitions. It is similarly - but not at all equally - difficult to decipher the meaning of rap recursive lyrics, as it is to interpret genome regulation... [The two statements discarding Crick's Central Dogma and Ohno's Junk DNA are shown by highlighted italics - AJP]

In the dorsal or ventral, makin' proteins. Top-down, secretin' out, regulatin genes.

Here we go in the embrio-asymmetry. From the egg sac, holla back, regulatin' genes.

Jigga I don't like it if aint zinc finger or homeodomain, yo, regulatin' genes.

How you tell a cell it should be in the spleen? Or your lung? or your tongue? Yo, you regulate it's genes.

Wanna talk about development? Of a single cell into a gentleman?

Then pay attention to your head when it knocks, because it grew there thanks to HOX.

So many controls on when a gene is active. But I'm a just focus on transcription factors.

When the ventral signals inhibits cactus, that's what the SOG I call a chain reaction.

Each cell's got an identical genome, but we know the phenomenon of devo...

Depends on whether them genes is expressed. Don't be getting depressed, though it's getting complex.

Next thing is how a cell's picking which GATs (stretches of nucleotides) get chosen, like Yogi in a pic-in-ic basket.

Proteins and DNA? Some interesting chemistry cuz they gettin jiggy with some different affinities.

And if they bind then we're looking at the next phase: Block or recruit the RNA polymerase?

Whether on or off either occasion, regulated gene leads to differentiation.

In the ant or posterior, switching on things. Evo Devo, regulatin' genes.

On that non-coding region up or downstream, is a sight where you might get to regulate a gene.

Jigga head-to-tail patterning is a common theme, from a fly to a guy, check it, regulatin' genes.

Aint an issue in the tissue when we makin' blood veins. In the HOX fam, hot damn, regulatin' genes.

Hey yo, talking bout development? Of a single cell into a gentleman?

Pay attention to your spine when it pops, cuz it grew there thanks to HOX.

Contemplating Evo Devo when I got to thinkin' how many years of evolution been tinkerin?

Like 1,000,000,000. No one quite knows when HOX genes rolled up.

Showed up with their ability to regulate-segmentation whether in a mouse or in invertebrate.

I heard'em say the gap genes is turning on the pair rule (genes)...

Regulatin' H-O-X?

Got ot be careful!

The truth is for mutant Hox, my homie got it.Gotta be careful with the genes that homeotic

Mutate them on or off then you in trouble. You get some strange phenotypes including…Double (Bi) thorax, but the most whack is the gross fact…

You can grow a leg where antennae shoulda grown at!

Unbelievable? Aint no embellishment. Regulatin' genes is crucial to development.

How can a single fertilized egg turn into a full-fledged organism? The two rappers at Stanford University provide the answer in the above video: “Regulatin’ Genes.” I’m happy to present it there, both because it’s so well done and because it’s yet another in our collection of songs whose lyrics include “polymerase.” (Although this one doesn’t include “polymerase chain reaction,” as Lab readers managed to do in response to “The P.C.R. Song.”)

The rapper on the left is Derrick Davis, a junior at Stanford. The rapper on the right is Tom McFadden, an instructor in the human biology program there. “While the lyrics are original,” Mr. McFadden told me, “the song is actually a parody of Jay-Z’s “Money Ain’t a Thang”. In their video, they have so much money that they flip through it, throw it up in the air, throw it out of moving vehicles. Since we just had midterms, I’m projecting some wishful thinking in the video - that there are so many A+’s on the midterm that we can just throw them in the air.”

And just in case you don’t follow every nuance in the video, like the Hox reference, here’s Mr. McFadden’s non-rap summary of the biology lesson:

Since virtually all cells have the same genome, cell specialization (for example: whether a cell becomes a neuron or a skin cell) is largely controlled by which genes are actually transcribed in a given cell. This can be controlled by transcription factors - proteins which bind to DNA and interact with the cellular machinery to control gene expression. An important family of transcription factors are Hox genes, which control which body parts grow where.

Hox genes control where legs, wings, and antennae grow in the fruit fly (so mutating them leads to some strange creatures). These same Hox genes have been highly conserved during evolution, and control vertebrae specialization in mice and humans. This helps to bring home a main lesson of developmental biology: that creating different body forms isn’t so much about what genes you have, but how you regulate them.

New York Times blog

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