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The Decade of FractoGene: From Discovery to Utility; Proofs of Concept Open Genome-Based Clinical Applications; Andras J. Pellionisz, 2012 International Journal of Systemics, Cybernetics and Informatics, Proceedings (ISSN 0973-4864) pp. 17-28
Fractal Defects Clog Recursive Genome Function


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The Decade of FractoGene: From Discovery to Utility - Proofs of Concept Open Genome-Based Clinical Applications. International Journal of Systemics, Cybernetics and Informatics, Proceedings of Hyderabad Conference (ISSN 0973-4864) pp. 17-28



The Decade of FractoGene: From Discovery to Utility:
Proofs of Concept Open Genome-Based Clinical Applications


Andras J. Pellionisz

HolGen Technology, Inc.
Sunnyvale, Silicon Valley, California

holgentech_at_gmail_dot_com


Abstract

February 15, 2012 - exactly to the day of a decade after the FractoGene discovery - a Guest of Honor Keynote Lecture was delivered in Hyderabad, upon gracious invitation by Prof. Govindarajan Ethirajan at the International Conference on Systemics, Cybernetics and Informatics. A 3-state lecture tour ensued (Bangalore, Hyderabad, Trivandrum), brilliantly organized by domain expert Ramanujam Venkata, to plant the seed for a global and scalable business model of industrialization of genomics by Silicon Valley California cooperating with „Silicon Valley” of India. Proceedings here comprise the presented decade-young science foundation by FractoGene with the first independent experimental proof of concept announced at the time of the lectures. Moreover, a public prediction was made at the talks, proven to be correct here and now, that „further PoC-s would appear in half a dozen or so major top papers in about 6 months”. Now 30+ follow-ups document that fractal defects are implicated not only in cancer but in a slew of genome-regulation diseases. Rapid progress also led to landmark announcements. On one hand, ENCODE, first concluded in 2007, cleared the ground for a quantum leap in conceptual and industrial advances by nullifying a fundamental axioms of Genomics were finally rendered obsolete by September 6, 2012. On the other hand, since science abhors vacuum, simultaneous replacement-concepts could fill the void by the novel Springer publication of geometrical unification of neuroscience and genomics in academia. Further, this author announced the industrial breakthrough that FractoGene was issued on Oct. 2nd 2012 by U.S. Patent Office No. 8,280,641 and thus a big picture opened looking to clinical applications, especially in BRIC countries.

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2012, Oct. 01, Germline Copy Number Variation and Cancer Risk. eLS., de Voer, R. M., Venkatachalam, R., van Kessel, A. G. and Kuiper, R. P. , DOI: 10.1002/9780470015902.a0023854, Int J Cancer. doi: 10.1002/ijc.27879 http://www.els.net/WileyCDA/ElsArticle/refId-a0023854.html

2012, Oct. 01, Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma., Staaf J, Isaksson S, Karlsson A, Jönsson M, Johansson L, Jönsson P, Botling J, Micke P, Baldetorp B, Planck M. Int J Cancer. doi: 10.1002/ijc.27879. http://www.ncbi.nlm.nih.gov/pubmed/23023297

2012, Oct. 02, Andras J. Pellionisz; U.S. patent No. 8,280,641 issued on Oct.2nd, 2012 for a “Utility of Genomic Fractals Resulting in Fractals of Organisms” http://www.prweb.com/releases/2012/10/prweb9962472.htm

2012, Oct. 04, Comprehensive molecular portraits of human breast tumours, The Cancer Genome Atlas Network; Nature 490, 61–70 doi:10.1038/nature11412 http://www.nature.com/nature/journal/v490/n7418/pdf/nature11412.pdf

2012, Oct 11, Characterization of germline copy number variation in high-risk African American families with prostate cancer, Elisa M. Ledet, Xiaofeng Hu, Oliver Sartor, Walter Rayford, Marilyn Li, Diptasri Mandal, The Prostate, DOI: 10.1002/pros.22602, http://onlinelibrary.wiley.com/doi/10.1002/pros.22602/abstract

2012, Oct. 15, Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysis. Kikuchi A, Ishikawa T, Mogushi K, Ishiguro M, Iida S, Mizushima H, Uetake H, Tanaka H, Sugihara K.; Int J Cancer. doi: 10.1002/ijc.27911. http://www.ncbi.nlm.nih.gov/pubmed/23065711

2012, Oct. 18, Histotype-specific copy-number alterations in ovarian cancer, Ruby YunJu Huang, Geng Bo Chen, Noriomi Matsumura, Hung-Cheng Lai, Seiichi Mori, Jingjing Li, Meng Kang Wong,Ikuo Konishi, Jean-Paul Thiery and Liang K Goh, BMC Medical Genomics, 5:47 doi:10.1186/1755-8794-5-47, http://www.biomedcentral.com/1755-8794/5/47/abstract

2012, Oct 20, Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma, Johan Staaf, Sofi Isaksson, Anna Karlsson, Mats Jönsson, Leif Johansson, Per Jönsson, Johan Botling, Patrick Micke, Bo Baldetorp, Maria Planck, DOI: 10.1002/ijc.27879, International Journal of Cancer, http://onlinelibrary.wiley.com/doi/10.1002/ijc.27879/abstract

2012, Microarray data verification and rapid screening for copy number alterations in cancer samples using qBiomarker Copy Number PCR Arrays, Sally Yousif, Kara Pascarelli, Quan Peng, Ying Zhang, LesleyAnn Hawthorne, Dominique Broccoli and Samuel Long QIAGEN News 2012 e4, http://www.qiagen.com/literature/qiagennews/weeklyarticle/12_06/e4/default.aspx?r=8348&WT.mc_id=NEWS072012CNPathwayFocusedPCRArrays

2012, Oct. 24, Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes; Nature (2012) Andrew V. Biankin, Nicola Waddell, Karin S. Kassahn, Marie-Claude Gingras, Lakshmi B. Muthuswamy et al. doi:10.1038/nature11547, http://www.nature.com/nature/journal/vaop/ncurrent/full/nature11547.html

2013, Andras J. Pellionisz, Roy Graham, Peter A. Pellionisz and Jean-Claude Perez. Recursive Genome Function of the Cerebellum: Geometric Unification of Neuroscience and Genomics. In: Springer Handbook; "The Cerebellum and Cerebellar Disorders", Ed. by M. Manto. M. Manto, D.L. Gruol, J.D. Schmahmann, N. Koibuchi, F. Rossi (eds.), Handbook of the Cerebellum and Cerebellar Disorders, pp. 1381-1423, DOI 10.1007/978-94-007-1333-8_61, Science+Business Media Dordrecht http://www.junkdna.com/pellionisz_unification/ full .pdf http://www.scribd.com/doc/111439455/BOOK-Unification-of-Neuroscience-and-Genomics-Pellionisz-Et-Al-in-Section-4-Springer-the-Cerebellum-Handbook-2012