Citation (Cut & Paste)
# in List of Publications
View & Download pdf versions
The Decade of FractoGene: From Discovery to Utility; Proofs of Concept Open Genome-Based Clinical Applications; Andras J. Pellionisz, 2012 International Journal of Systemics, Cybernetics and Informatics, Proceedings (ISSN 0973-4864) pp. 17-28
Fractal Defects Clog Recursive Genome Function

Full .pdf of paper is available here
The Decade of FractoGene: From Discovery to Utility - Proofs of Concept Open Genome-Based Clinical Applications. International Journal of Systemics, Cybernetics and Informatics, Proceedings of Hyderabad Conference (ISSN 0973-4864) pp. 17-28

The Decade of FractoGene: From Discovery to Utility:
Proofs of Concept Open Genome-Based Clinical Applications

Andras J. Pellionisz

HolGen Technology, Inc.
Sunnyvale, Silicon Valley, California



February 15, 2012 - exactly to the day of a decade after the FractoGene discovery - a Guest of Honor Keynote Lecture was delivered in Hyderabad, upon gracious invitation by Prof. Govindarajan Ethirajan at the International Conference on Systemics, Cybernetics and Informatics. A 3-state lecture tour ensued (Bangalore, Hyderabad, Trivandrum), brilliantly organized by domain expert Ramanujam Venkata, to plant the seed for a global and scalable business model of industrialization of genomics by Silicon Valley California cooperating with „Silicon Valley” of India. Proceedings here comprise the presented decade-young science foundation by FractoGene with the first independent experimental proof of concept announced at the time of the lectures. Moreover, a public prediction was made at the talks, proven to be correct here and now, that „further PoC-s would appear in half a dozen or so major top papers in about 6 months”. Now 30+ follow-ups document that fractal defects are implicated not only in cancer but in a slew of genome-regulation diseases. Rapid progress also led to landmark announcements. On one hand, ENCODE, first concluded in 2007, cleared the ground for a quantum leap in conceptual and industrial advances by nullifying a fundamental axioms of Genomics were finally rendered obsolete by September 6, 2012. On the other hand, since science abhors vacuum, simultaneous replacement-concepts could fill the void by the novel Springer publication of geometrical unification of neuroscience and genomics in academia. Further, this author announced the industrial breakthrough that FractoGene was issued on Oct. 2nd 2012 by U.S. Patent Office No. 8,280,641 and thus a big picture opened looking to clinical applications, especially in BRIC countries.


1629, Descartes R, Treatise of man. Prometheus Books (in English, 2003)

1934, Bertalanffy L, Untersuchungen uber die Gesetzlichkeit des Wachstums. I. Allgemeine Grundlagen der Theorie; mathematische und physiologische Gesetzlichkeiten des Wachstums bei Wassertieren. Arch Entwicklungsmech 131:613–652

1944, Schroedinger E, What is life? Dublin Institute for Advanced Studies at Trinity College, Dublin, in Feb 1943.

1948, Wiener N, Cybernetics or control and communication in the cnimal and the machine. Hermann & Cie Editeurs/The Technology Press/Wiley, Paris, Cambridge, MA, New York.Ľsr_1_1?ieĽUTF8&qidĽ1319564993&srĽ8-1

1969, Kauffman, S.A. Metabolic stability and epigenesis in randomly constructed genetic nets, Journal of Theoretical Biology, Vol. 22, issue 3, pp. 437-467.

1983, Mandelbrot, B, The fractal geometry of nature, Mandelbrot, B., 2nd edn. Freeman, New York

1987, Gleick, J, Chaos: Making a New Science, Viking Penguin

1989, Pellionisz, AJ, Neural geometry: towards a fractal model of neurons; In: Cotterill RMJ (ed) Models of brain function. Cambridge University Press, Cambridge, pp 453–464

1993, Grosberg A, Rabin Y, Havlin S, Neer A; Crumpled globule model of the three-dimensional structure of DNA. Europhys Lett 23:373–378.

1994, Peng C.K, Buldyrev SV, Hausdorff, J.M., Havlin S, Mietus JE, Simons M, Stanley HE and Goldberger AL; Fractal Landscapes in Physiology & Medicine: Long-Range Correlaions in DNA sequences and Heart Rate Intervals,; In: Fractals in Biology and Medicine, T.F. Nonnenmacher, G.A. Losa, E.R. Weibel (eds), Birkhauser. Pp. 55-64

1998, Rigoutsos I, Floratos A, Combinatorial pattern discovery in biological sequences: the TEIRESIAS algorithm. Bioinformatics 14(1):55–67, pmid:9520502

2000, Lander E. A Hypothesis-free Search for Genes. Keystone Millenium Meeting: A Trends Guide, Page 48 in Neurosciences at the Postgenomic Era, by Jacques Mallet, Yves Christen, Springer, 2003

2001, As the Future Catches You: How Genomics & Other Forces Are Changing Your Life, Work, Health & Wealth, Juan Enriquez, Crown Publisher, ISBN 0-609-60903-3

2002, Hood LR, Timp W, Bravo HC, Sabunciyan, Langmead B, McDonald OG et al., My life and adventures integrating biology and technology. Commemorative lecture given when awarded the 2002 Kyoto Prize in Advanced Technologies

2002, Plotkin, H; Junk DNA Revisited. Silicon Valley startup claims to have unlocked a key to its hidden language. San Francisco Chronicle,

2003, Pellionisz, A; FractoGene Design-Tool for Protein-Based Self-Assembling Nanostructures, Materials and Applications, Keynote Lecture of the 204th Electrochemical Society, pp. 1195, 2003

2003, Rajan EG; Symbolic computing, BS Publication pp. 183-189 Fig. 11.3.2.

2004, Oct, Detrended fluctuation analysis of genome-wide copy number profiles of glioblastomas using array-based comparative genomic hybridization, Yukiko Nakahara, Tetsuya Shiraishi, Hiroaki Okamoto, Toshihiro Mineta,Tsuyoshi Oishi, Kohsuke Sasaki, Kazuo Tabuchi, Neuro Oncol 6 (4):281-289.doi: 10.1215/S1152851703000632

2006, March 4, Short blocks from the noncoding parts of the human genome have instances within nearly all known genes and relate to biological processes; Isidore Rigoutsos, Tien Huynh, Kevin Miranda, Aristotelis Tsirigos, Alice McHardy, and Daniel Platt, IBM Thomas J. Watson Research Center, PNAS, vol. 103 no. 17 , 6605– 6610

2006, Bansley MF; Superfractals; Cambridge University Press, Cambridge

2006, Pellionisz, A, PostGenetics: Genetics beyond Genes. The journey of discovery of the function of "junk" DNA. Peer-invited and peer-reviewed Keynote lecture at "European Inaugural of the International PostGenetics Society", 12. October, 2006, Budapest, Hungary, a Satellite to the International Congress of Immunogenomics and Immunomics, pp. 219., BCII2006

2006, Simons M, Pellionisz A, Genomics, morphogenesis and biophysics: triangulation of purkinje cell development. The Cerebellum 5(1):27–35.

2007 June 13, New Findings Challenge Established Views on Human Genome, ENCODE Research Consortium Uncovers Surprises Related to Organization and Function of Human Genetic Blueprint, Nature, Special Issue

2007, Pellionisz A; FractoGene CIP submission to USPTO October 18, 2007 “Utility of Genomic Fractals Resulting in Fractals of Organisms”

2007 Dec. 02, Mark B. Gerstein, Can Bruce, Joel S. Rozowsky, Deyou Zheng, Jiang Du, Jan O. Korbel, Olof Emanuelsson, Zhengdong D. Zhang, Sherman Weissman, and Michael Snyder; What is a gene, post-ENCODE? History and updated definition; doi:10.1101/gr.6339607 Genome Res. 2007 17: 669-681

2008, Fiori S, Lie-group-type neural system learning by manifold retractions. Neural Netw, 21(10):1524–1529.

2008, Pellionisz, A; The Principle of Recursive Genome Function, A.; The Cerebellum. 2008;7(3):348-59. Full .pdf
Supplementary material

2008, October 30, Is IT Ready for the Dreaded DNA Data Deluge? YouTube

2008, Shapshak P, Chiappelli, F, Commins D, Singer E, Levine AJ, Somboonwit C, Minagar A, Pellionisz, A (2008) Molecular epigenetics, chromatin, and NeuroAIDS/HIV: translational implications. Bioinformation 3(1):53–57. PMCID: PMC2586134

2008, Chiappelli F, Shapshak P, Commins D, Singer E, Minagar E, Oluwadara O et al (2008) Molecular epigenetics, chromatin, and NeuroAIDS/HIV: immunopathological implications. Bioinformation 3(1):47–52.

2008 Dec. 4, Clayton M. Christensen , Jerome H. Grossman M.D. , Jason Hwang M.D.; The Innovator's Prescription: A Disruptive Solution for Health Care, McGraw-Hill Prof Med/Tech, Dec 4, 2008 - 496 pages

2009, Cartieri FJ (2009) Darwinism and Lamarckism before and after Weisman: a historical, philosophical, and methodological analysis. University of Pittsburg, pp 1–54.

2009, (September 16) Pellionisz A, From the Principle of Recursive Genome Function of HoloGenome Regulation by Personal Genome Computers (Cold Spring Harbor Labs “Personal Genomes II.” invited by George Church)

2009, (October 9) Erez Lieberman-Aiden, Nynke L. van Berkum, Louise Williams, Maxim Imakaev, Tobias Ragoczy, Agnes Telling, Ido Amit, Bryan R. Lajoie, Peter J. Sabo, Michael O. Dorschner, Richard Sandstrom, Bradley Bernstein, M. A. Bender, Mark Groudine, Andreas Gnirke, John Stamatoyannopoulos, Leonid A. Mirny, Eric S. Lander, Job Dekker (2009 October 9) The comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science 326. doi: 10.1126/science.1181369
Full .pdf at

2009, May, Haverty PM, Hon LS, Kaminker JS, Chant J, Zhang Z.; High-resolution analysis of copy number alterations and associated expression changes in ovarian tumors. BMC Med Genomics; 6;2(1):21. [Epub ahead of print] Ingenuity Systems provides further 38 ”Copy Number” papers in their website

2009, Feng Zhang, Wenli Gu, Matthew E. Hurles, and James R. Lupski; Copy Number Variation in Human Health, Disease, and Evolution; Annu. Rev. Genomics Hum. Genet. 2009. pp. 10:451–81. The Annual Review of Genomics and Human Genetics, 10.1146/annurev.genom.9.081307.164217,

2009, Nov. 26, Richard Redon, Shumpei Ishikawa, Karen R. Fitch, Lars Feuk, George H. Perry, T. Daniel Andrews et al., Global variation in copy number in the human genome, Nature. 2006 November 23; 444(7118): 444–454.doi: 10.1038/nature05329

2010 Jan. 05, Francis Collins; The Language of Life: DNA and the Revolution in Personalized Medicine, HarperCollins Publishers, ISBN 978-0-06-173317-8

2010, Codon population in single-stranded whole human genome DNA are fractal and fine-tuned by the Golden Ration 1.618. Perez JC, Interdiscip Sci: Comput Life Sci 2(3):228–340. doi:10.1007/s12539-010-0022-0, .

2010, Arneth BM, Sequence variability and sequence evolution: An explanation of molecular polymorphisms and why many molecular structures can be preserved although they are not predominant. DNA Cell Biol 29(10):571–576. doi:10.1089/dna.2009.0942

2010, Oller JW; The antithesis of entropy, Biosemiotic communication from genetics to human language with special emphasis on the Iimmune systems. Entropy 12:631–705. doi:10.3390/e12040631.

2010, Sept 1, Schadt EE, Linderman MD, Sorenson J, Lee L, Nolan GP; Computational solutions to large-scale data management and analysis. Nature Rev Genet (11):647–amp;657.

2011, Stagnaro S (2011) Glycocalix quantum-biophysical-semeiotic evaluation plays a central role in demonstration of water memory-information.

2011, Stagnaro S, Caramel S (2011) A new way of therapy based on water memory-information: the Quantum biophysical approach.

2011, Alexei Fedorov and Larisa Fedorova: An Intricate Mosaic of Genomics Patterns at Mid-range Scale. Chapter 3. in: Advances in Genomic Sequence Analysis and Pattern Discovery. Science Engineering and Biology Informatics. Vol. 7. World Scientific, Singapore, pp 65–93 Editors Laura Elnitski, Helen Piontkivska, Lonnier Welch.

2011, February 02, Ryan E. Mills, Klaudia Walter, Chip Stewart, Robert E. Handsaker, Ken Chen, Can Alkan, Alexej Abyzov, Seuntai Chris Yoon, Kai Ye, R. Keira Cheetham, Asif Chinwalla, Donald F. Conrad, Yutao Fu, Fabian Grubert, Iman Hajirasouliha, Fereydoun Hormozdiari et al; Mapping copy number variation by population scale genome sequencing, Nature 470, 59–65 doi:10.1038/nature09708

2011 Feb. 09, Michael F. Berger, Michael S. Lawrence, Francesca Demichelis, Yotam Drier, Kristian Cibulskis, Andrey Y. Sivachenko, Andrea Sboner, Raquel Esgueva, Dorothee Pflueger, Carrie Sougnez, Robert Onofrio, Scott L. Carter, Kyung Park, Lukas Habegger, Lauren Ambrogio, Timothy Fennell, Melissa Parkin, Gordon Saksena, Douglas Voet, Alex H. Ramos, Trevor J. Pugh, Jane Wilkinson, Sheila Fisher, Wendy Winckler, Scott Mahan, Kristin Ardlie, Jennifer Baldwin, Jonathan W. Simons, Naoki Kitabayashi, Theresa Y. MacDonald, Philip W. Kantoff, Lynda Chin, Stacey B. Gabriel, Mark B. Gerstein, Todd R. Golub, Matthew Meyerson, Ashutosh Tewari, Eric S. Lander, Gad Getz, Mark A. Rubin, Levi A. Garraway; The genomic complexity of primary human prostate cancer, Nature. 470, 214-220, doi:10.1038/nature 09744

2011 July 03, DNA secondary structures and epigenetic determinants of cancer genome evolution, Subhajyoti De, Franziska Michor, Nature Structural & Molecular Biology, 18, 950-955, doi: 10.1038/nsmb.2089

2011 July 18, Petoukhov, Sergey V; The genetic code, 8-dimensional hypercomplex numbers and dyadic shifts. International Conference on Bioinformatics & Computational Biology (Las Vegas, USA, July 18-21, 2011)

2011 Nov. 20, Fudenberg G, Getz G, Meyerson M, Mirny L.A; High order chromatin architecture shapes the landscape of chromosomal alterations in cancer, Nat Biotechnol.;29(12):1109-13. doi: 10.1038/nbt.2049.

2012 Jan. 31. Eric Topol, The Creative Destruction of Medicine: How the Digital Revolution Will Create Better Health Care, Basic Books (Perseus Book Group), ISBN-10: 0465025501

2012 Feb. 07, Ana CV Krepischi , Maria Isabel W Achatz , Erika MM Santos, Silvia S Costa, Bianca CG Lisboa, Helena Brentani, Tiago M Santos, Amanda Gonçalves, Amanda F Nóbrega, Peter L Pearson, Angela M Vianna-Morgante, Dirce M Carraro , Ricardo R Brentani and Carla Rosenberg; Germline DNA copy number variation in familial and early-onset breast cancer, , Breast Cancer Research, 14:R24 doi:10.1186/bcr3109

2012 February 17, Yoshinori Nishino, Mikhail Eltsov, Yasumasa Joti, Kazuki Ito, Hideaki Takata, Yukio Takahashi, Saera Hihara, Achilleas S Frangakis, Naoko Imamoto, Tetsuya Ishikawa and Kazuhiro Maeshima; Human mitotic chromosomes consist predominantly of irregularly folded nucleosome fibres without a 30-nm chromatin structure,

2012 February 17, Tamar Schlick, Jeff Hayes and Sergei Grigoryev; Toward Convergence of Experimental Studies and Theoretical Modeling of the Chromatin Fiber, doi: 10.1074/jbc.R111.305763 The Journal of Biological Chemistry, 287, 5183-5191.

2012 March 13 Human mitotic chromosome structure: what happened to the 30-nm fibre? Jeffrey C Hansen The EMBO Journal 31, 1621–1623. doi:10.1038/emboj.2012.66; Published online 13 March 2012

2012 Apr. 23. Fan B, Dachrut S, Coral H, Yuen ST, Chu KM, et al.;Integration of DNA Copy Number Alterations and Transcriptional Expression Analysis in Human Gastric Cancer. PLoS ONE 7(4): e29824. doi:10.1371/journal.pone.0029824|utmccn=(direct)|utmcmd=(none)&__utmv=-&__utmk=98462684

2012 April, Ondrej Podlaha, Markus Riester, Subhajyoti De and Franziska Michor; Evolution of the cancer genome, Trends in Genetics, Vol. 28, No. 4,

2012 Apr. 28, Copy Number Aberrations Define Breast Cancer Subgroups, doi: 10.1158/2159-8290.CD-RW2012-054

2012 May 06, Guichard C, Amaddeo G, Imbeaud S, Ladeiro Y, Pelletier L, Maad IB,Calderaro J,Bioulac-Sage P, Letexier M, Degos F, Clément B, Balabaud C, Chevet E, Laurent A, Couchy G, Letouzé E, Calvo F and Zucman-Rossi; Integrated analysis of somatic mutations and focal copy-number changes identifies key genes and pathways in hepatocellular carcinoma. Nat Genet. 44:694-8.

2012 May 20, Catherine S. Grasso et al.; The mutational landscape of lethal castration-resistant prostate cancer. Nature, 487, 239-243 doi:10.1038/nature11125

2012 May 31, Alexander Pearlman, Christopher Campbell, Eric Brooks, Alex Genshaft, Shahin Shajahan, Michael Ittman, G. Steven Bova, Jonathan Melamed, Ilona Holcomb, Robert J. Schneider, Harry Ostrer; Clustering-Based Method for Developing a Genomic Copy Number Alteration Signature for Predicting the Metastatic Potential of Prostate Cancer, Journal of Probability and Statistics, Article ID 873570, 19 pages, doi:10.1155/2012/873570

2012 June 01, Sanjiban Chakrabarty, Reena R. D’Souza, Ravishankara Bellampalli, Harish Rotti, Abdul V. Saadi, Puthiya M. Gopinath, Raviraja V. Acharya, Periyasamy Govindaraj, Kumarasami Thangaraj, Kapaettu Satyamoorthuy; Comprehensive DNA copy number profile and BAC library construction of an Indian individual, Gene Vol (500), issue 2, pp. 186-193

2012 June 05, David S. Rickman, T. David Soong, Benjamin Moss. Oncogene-mediated alterations in chromatin conformation. Edited* by Eric S. Lander, The Broad Institute of MIT and Harvard, Cambridge, MA, Published online before print May 21, 2012, doi:10.1073/pnas.1112570109PNAS June 5, 2012 vol. 109no. 23 9083-9088 full.pdf “Interaction Data Support the Fractal Globule Model of Nuclear Organization”.

2012 June 21, The landscape of cancer genes and mutational processes in breast cancer, Philip J. Stephens, Patrick S. Tarpey, Helen Davies, Peter Van Loo, Chris Greenman, David C. Wedge, Serena Nik-Zainal, Sancha Martin, Ignacio Vareia, Graham R. Bignell, Lucy R. Yates, et al; Nature 486, 400–404 doi:10.1038/nature11017,

2012 June, The biological correlates of macroscopic breast tumour structure measured using fractal analysis in patients undergoing neoadjuvant chemotherapy. P P Di Giovanni, T S TS Ahearn, S I K SI Semple, L M LM Lovell, I I Miller, F J FJ Gilbert, T W TW Redpath, S D SD Heys and R T RT Staff, Breast Cancer Res Treat 133(3):1199-206 (2012), PMID DOI:10.1007/s10549-012-2014-8,

2012, July 19, Comprehensive molecular characterization of human colon and rectal cancer, The Cancer Genome Atlas Network, Nature 487, 330–337, doi:10.1038/nature11252

2012, Jul 25-Nov, Identification of frequent BRAF copy number gain and alterations of RAFgenes in chinese prostate cancer, Guoping Ren, Xiaoyan Liu, Xueying Mao, Yanling Zhang, Elzbieta Stankiewicz, Lucy Hylands, Rongrong Song, Daniel M. Berney, Jeremy Clark, Colin Cooper, Yong-Jie Lu, Genes, Chromosomes and Cancer, 51(11) pp. 1014-1023, DOI: 10.1002/gcc.21984

2012, Aug. 02, Rare de novo germline copy-number variation in testicular cancer. Stadler ZK, Esposito D, Shah S, Vijai J, Yamrom B, Levy D, Lee YH, Kendall J, Leotta A, Ronemus M, Hansen N, Sarrel K, Rau-Murthy R, Schrader K, Kauff N,Klein RJ, Lipkin SM, Murali R, Robson M, Sheinfeld J, Feldman D, Bosl G, Norton L, Wigler M, Offit K., Am J Hum Genet. 2012 Aug 10;91(2):379-83. doi: 10.1016/j.ajhg.2012.06.019.

2012, Aug. 08, Germline copy number variation and ovarian cancer survival, Brooke L. Fridley, Prabhakar Chalise, Ya-Yu Tsai, Zhifu Sun,Robert A. Vierkant, Melissa C. Larson, Julie M. Cunningham, Edwin S. Iversen, David Fenstermacher, Jill Barnholtz-Sloan, Yan Asmann, Harvey A. Risch, Joellen M. Schildkraut, Catherine M. Phelan, Rebecca Sutphen, Thomas A. Sellers and Ellen L. Goode, Frontiers of Genetics, doi: 10.3389/fgene.2012.00142

2012, Aug 09, Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast, Shaoxi Liao, Mohamed M. Desouki, Daniel P. Gaile, Lori Shepherd, Norma J. Nowak, Jeffrey Conroy, William T. Barry, Joseph Geradts, Genes, Chromosomes and Cancer, Vol 51(12) pp. 1067-1078,

2012, Aug. 16, Comparative Analysis of Somatic Copy-number Alterations across Different Human Cancer Types Reveals Two Distinct Classes of Breakpoint Hotspots, Yudong Li, Li Zhang, Robyn L. Ball, Xinle Liang, Jianrong Li, Zhenguo Lin, Han Liang, Hum. Mol. Genet. (2012)doi: 10.1093/hmg/dds340

2012, Aug. 17, Cancer Vulnerabilities Unveiled by Genomic Loss, Cell 150, pp. 842–854,Deepak Nijhawan, Travis I. Zack, Yin Ren, Matthew R. Strickland, Rebecca Lamothe, Steven E. Schumacher, Aviad Tsherniak, Henrike C. Besche, Joseph Rosenbluh, Shyemaa Shehata, Glenn S. Cowley, Barbara A. Weir, Alfred L. Goldberg, Jill P. Mesirov, David E. Root, Sangeeta N. Bhatia, Rameen Beroukhim, William C. Hahn.

2012, Aug. 23, Correlating multiallelic copy number polymorphisms with disease susceptibility; Cantsilieris, S. and White, S. J.,. Hum. Mutat.. doi: 10.1002/humu.22172

2012, Aug. 24, Specific genomic regions are differentially affected by copy number alterations across distinct cancer types, in aggregated cytogenetic data., Kumar N, Cai H, von Mering C, Baudis M.PLoS One. 2012;7(8):e43689. doi: 10.1371/journal.pone. 0043689.

2012, Aug. 31, Simultaneous copy number gains of NUPR1 and ERBB2 predicting poor prognosis in early-stage breast cancer, Seung-Hyun Jung, Ah-Won Lee, Seon-Hee Yim, Hae-Jin Hu, Chungyoul Choi and Yeun-Jun Chung, BMC Cancer, 2012, 12:382 doi:10.1186/1471-2407-12-382,

2012 Sept. 06, An integrated encyclopedia of DNA elements in the human genome, The ENCODE Project Consortium, Ewan Birney (et al., ~350 authors), Nature, pp. 57-74 doi:10.1038/nature11247

2012 Sept. 13, The transcriptional landscape and mutational profile of lung adenocarcinoma; Genome Res., Jeong-Sun Seo, Young Seok Ju, Won-Chul Lee, et al. doi:10.1101/gr.145144.112, http://genome.cshlp

2012, Sept 27, Comprehensive genomic characterization of squamous cell lung cancers, The Cancer Genome Atlas Research Network, Nature 489, 519–525, doi:10.1038/nature11404

2012, Sept, Identification of germline genomic copy number variation in familial pancreatic cancerHuman Genetics, Vol 131 (9), pp 1481-1494, Wigdan Al-Sukhni, Sarah Joe, Anath C. Lionel, Nora Zwingerman, George Zogopoulos, Christian R. Marshall, Ayelet Borgida, Spring Holter, Aaron Gropper, Sara Moore, Melissa Bondy, Alison P. Klein, Gloria M. Petersen, Kari G. Rabe, Ann G. Schwartz, Sapna Syngal, Stephen W. Scherer,Steven Gallinger

2012, Oct. 01, Germline Copy Number Variation and Cancer Risk. eLS., de Voer, R. M., Venkatachalam, R., van Kessel, A. G. and Kuiper, R. P. , DOI: 10.1002/9780470015902.a0023854, Int J Cancer. doi: 10.1002/ijc.27879

2012, Oct. 01, Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma., Staaf J, Isaksson S, Karlsson A, Jönsson M, Johansson L, Jönsson P, Botling J, Micke P, Baldetorp B, Planck M. Int J Cancer. doi: 10.1002/ijc.27879.

2012, Oct. 02, Andras J. Pellionisz; U.S. patent No. 8,280,641 issued on Oct.2nd, 2012 for a “Utility of Genomic Fractals Resulting in Fractals of Organisms”

2012, Oct. 04, Comprehensive molecular portraits of human breast tumours, The Cancer Genome Atlas Network; Nature 490, 61–70 doi:10.1038/nature11412

2012, Oct 11, Characterization of germline copy number variation in high-risk African American families with prostate cancer, Elisa M. Ledet, Xiaofeng Hu, Oliver Sartor, Walter Rayford, Marilyn Li, Diptasri Mandal, The Prostate, DOI: 10.1002/pros.22602,

2012, Oct. 15, Identification of NUCKS1 as a colorectal cancer prognostic marker through integrated expression and copy number analysis. Kikuchi A, Ishikawa T, Mogushi K, Ishiguro M, Iida S, Mizushima H, Uetake H, Tanaka H, Sugihara K.; Int J Cancer. doi: 10.1002/ijc.27911.

2012, Oct. 18, Histotype-specific copy-number alterations in ovarian cancer, Ruby YunJu Huang, Geng Bo Chen, Noriomi Matsumura, Hung-Cheng Lai, Seiichi Mori, Jingjing Li, Meng Kang Wong,Ikuo Konishi, Jean-Paul Thiery and Liang K Goh, BMC Medical Genomics, 5:47 doi:10.1186/1755-8794-5-47,

2012, Oct 20, Landscape of somatic allelic imbalances and copy number alterations in human lung carcinoma, Johan Staaf, Sofi Isaksson, Anna Karlsson, Mats Jönsson, Leif Johansson, Per Jönsson, Johan Botling, Patrick Micke, Bo Baldetorp, Maria Planck, DOI: 10.1002/ijc.27879, International Journal of Cancer,

2012, Microarray data verification and rapid screening for copy number alterations in cancer samples using qBiomarker Copy Number PCR Arrays, Sally Yousif, Kara Pascarelli, Quan Peng, Ying Zhang, LesleyAnn Hawthorne, Dominique Broccoli and Samuel Long QIAGEN News 2012 e4,

2012, Oct. 24, Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes; Nature (2012) Andrew V. Biankin, Nicola Waddell, Karin S. Kassahn, Marie-Claude Gingras, Lakshmi B. Muthuswamy et al. doi:10.1038/nature11547,

2013, Andras J. Pellionisz, Roy Graham, Peter A. Pellionisz and Jean-Claude Perez. Recursive Genome Function of the Cerebellum: Geometric Unification of Neuroscience and Genomics. In: Springer Handbook; "The Cerebellum and Cerebellar Disorders", Ed. by M. Manto. M. Manto, D.L. Gruol, J.D. Schmahmann, N. Koibuchi, F. Rossi (eds.), Handbook of the Cerebellum and Cerebellar Disorders, pp. 1381-1423, DOI 10.1007/978-94-007-1333-8_61, Science+Business Media Dordrecht full .pdf