About HolGenTech, Inc.

HolGenTech, Inc. leads the way in Genome Computer Architecture for accelerated analysis with pure-play software addressing the applications for a Genome Based Economy. The Silicon Valley based company was founded on the basis of HoloGenomics: the synthesis of Genomics and Epigenomics expressed in Informatics calling for novel architectures of genome computing.

HolGenTech is foundational to the Genome Based Economy upon us. Much as it took Microsoft to create the utility of the personal computer, HolGenTech makes the personal genome work for us. Using software and accelerated computing power, HolGenTech unlocks personalized genome information for a world of applications in the Genome Based Economy.

First in the Genome Based Economy is Healthcare, about to change, and dramatically. New discoveries about the genome were revealed in June of 2007 with National Institutes of Health (NIH) revealing that 98.7 percent of genomic material had been unjustly ignored since the human genome was first mappped. Though tremendous funds were invested in genomics from the late 1980s into the new millennium, no proportional acceleration in cures for disease are on record. NIH's 2007 admission gave rise to a completely new investment opportunities and new hopes for genomics.

As such, the revelation was quickly followed by investment in full genome sequencing of all the now recognized genomic material, with Intel playing a big part in nano-sequencing technology investment. Nano-sequencing, especially the SMRT nano-sequencing due from Pacific Biosciences, promises to make personal genomes readily accessible and affordable to the average individual.

Ready to take advantage, healthcare is positioning to be the first industry to begin utilizing the new genome information for prevention before treatment and cure of diseases. The new healthcare model, also known as Personalized Medicine, is the first sector to move on what will be the "Genome Based Economy." Further catalyzing developments, the U.S. federal government is promoting Personalized Medicine - prevention before cure - in its plans for a new healthcare infrastructure.

Once the new nano-sequencing techniques are delivered, our genomes will become readily available to us to do with as we like, whether it be in discovering proclivities to disease and prevention or to recognizing best choices for promoting wellness and well being. Best choices from food to clothing to housing and environmental factors, even to friends, can be recognized through the information within our personal genome. When the personal genome is fully applied to our world and the choices we make in it, this is the Genome Based Economy.

However, once nano-sequencing is accomplished and we become objective holders of our personal genome, we must be able to "discover" our personal genome information for full application. This discovery requires both computing power and software to delve down into the information. By bringing the necessary software and accelerated computing power required, HolGenTech unlocks the personalized genome information for application of all types. HolGenTech both delivers the personal genome in full application for Personalized Medicine and engenders the whole field of a Genome Based Economy.

Where we are

HolGenTech is an early stage company and seeks funding in a timely fashion in order to be poised for full advantage when the avalanche of complete genome nano-sequencing from Pacific Biosciences is upon us, expected by the second half of 2010.

Notable milestones and next steps

HolGenTech software, as noted, has been written and is running on traditional computers, but too slowly,so far. Funding over the first 12 months will be used to port software to existing hardware hybrid platforms to benchmark accelerated computing and, in order to develop immediate applications for Personalized Medicine, which represents the first sector of demand from the Genome Based Economy. Companies such as 23andMe and Navigenics and other Direct-to-Customer (DTC) models for personalized genome access and utilization, are faced with the challenge to take applications down into the full genome to discover disease, proclivities and be able to offer therapies and solutions for health and well being.

To complete the "Direct-To-Customers" business model, HolGenTech demonstrated its Personal Genome Assistant (PDA turned into a PGA) using the Android smart phone, though personalized prevention by barcode shopping is agnostic to hardware platforms, both at the PDA or Personal Genome Computer (an HPC desktop) or their clusters for genome centers.

Note that today, gene sequencing of a single gene is offered to consumers for ~$1 by Complete Genomics, another nano-sequencing company. That means that anyone with a dollar can begin to examine their genome, one gene at a time, perhaps looking for a tendency to a particular disease they fear they may have inherited. However, without the software, based on algorithmic approaches - without HolGenTech - they are unlikely to have an understanding of genome regulation, but only a fractional knowledge of the one gene and its structure. In other words, they can't use the gene information or calibrate choices to make any change to a known proclivity or disease. With the demand for genome utilization created by breakthrough affordability and access - a gene for $1 - so follows the demand to know more and affect one's circumstances and state of being.

HolGenTech founder, Dr. Andras Pellionisz' bio is here